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You should not use Janumet if you are allergic to metformin (Actoplus Met, Avandamet, Fortamet, Glucophage, Riomet) or sitagliptin (Januvia), or if you have:

kidney or liver disease; or
if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Some people develop a life-threatening condition called lactic acidosis while taking metformin. You may be more likely to develop lactic acidosis if you have liver or kidney disease, congestive heart failure, a severe infection, if you are dehydrated, or if you drink large amounts of alcohol. Talk with your doctor about your individual risk.

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Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs.

FDA pregnancy category B. Janumet is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether metformin or sitagliptin passes into breast milk or if it could harm a nursing baby. Do not use Janumet without telling your doctor if you are breast-feeding a baby.

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